Weight & Metabolism
Approved medicines and investigational metabolic peptides, separated by indication and evidence maturity.
ASK BETTER QUESTIONS
What changes a weight & metabolism evidence decision?
- Which options have FDA-reviewed indications?
- Where are phase 2 signals being mistaken for approval?
- How do compounded products differ from approved medicines?
EVIDENCE RECORDS
Weight & Metabolism evidence records.
Semaglutide
Semaglutide has a mature evidence base, but claims must remain tied to the specific product, indication, population, and label.
Open evidence recordTirzepatide
Tirzepatide is an approved dual-receptor medicine with a mature human evidence base; it is not interchangeable with investigational retatrutide.
Open evidence recordRetatrutide
Retatrutide has meaningful randomized human evidence, but it should not be described as an available approved alternative to semaglutide or tirzepatide.
Open evidence recordAOD-9604
AOD-9604 is a useful example of why preclinical promise is not enough: substantial human development did not produce persuasive efficacy or an approved obesity indication.
Open evidence recordDIRECT COMPARISONS