How do tesamorelin, sermorelin, CJC-1295, and ipamorelin differ?
They all interact with the growth-hormone axis, but through different receptors, with very different clinical and regulatory maturity.
DIRECT ANSWER
Evidence-based answer.
They all interact with the growth-hormone axis, but through different receptors, with very different clinical and regulatory maturity.
Reviewed August 7, 2026. Each statement links to its evidence record, followed by the primary and official sources used for this answer.
Tesamorelin is a GHRH analog with one narrow FDA-approved indication and multiple randomized trials.
Open evidence recordSermorelin has historical human use; CJC-1295 has early hormone-response studies; neither has a current FDA-approved product.
Open evidence recordIpamorelin acts at the ghrelin receptor. FDA has documented compounding safety and characterization concerns.
Open evidence recordPRIMARY & OFFICIAL SOURCES
Sources for this answer.
3 source records, with duplicates removed.